Article

Identification of a Binding Site for Small Molecule Inhibitors Targeting Human TRPM4

2024-01-23

Abstract excerpt

Transient receptor potential (TRP) melastatin 4 (TRPM4) protein is a calcium-activated monovalent cation channel associated with various genetic and cardiovascular disorders. The anthranilic acid derivative NBA is a potent and specific TRPM4 inhibitor, but its binding site in TRPM4 has been unknown, although this information is crucial for drug development targeting TRPM4. We determined three cryo-EM structures of...

Identifiers and source

Literature Corpus work: a79ca96e-4caa-5bce-8b35-ed6c8ccba0d1
DOI: 10.1101/2024.01.22.576650

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