Article
Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms.
Nature structural & molecular biology - 1 Mar 2018
Deng Zengqin, Paknejad Navid, Maksaev Grigory, Sala-Rabanal Monica, Nichols Colin G, Hite Richard K, Yuan Peng
Abstract excerpt
The transient receptor potential (TRP) channel TRPV4 participates in multiple biological processes, and numerous TRPV4 mutations underlie several distinct and devastating diseases. Here we present the cryo-EM structure of Xenopus tropicalis TRPV4 at 3.8-Å resolution. The ion-conduction pore contains an intracellular gate formed by the inner helices, but lacks any extracellular gate in the selectivity filter, as...
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