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Article

Nonsensing residues in S3-S4 linker's C terminus affect the voltage sensor set point in K+ channels.

The Journal of general physiology - 5 Feb 2018

Carvalho-de-Souza Joao L, Bezanilla Francisco

Abstract excerpt

Voltage sensitivity in ion channels is a function of highly conserved arginine residues in their voltage-sensing domains (VSDs), but this conservation does not explain the diversity in voltage dependence among different K+ channels. Here we study the non-voltage-sensing residues 353 to 361 in Shaker K+ channels and find that residues 358 and 361 strongly modulate the voltage dependence of the channel. We mutate...

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Identifiers

PMID: 29321262
DOI: 10.1085/jgp.201711882
PMCID: PMC5806678

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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