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Article

Voltage-insensitive gating after charge-neutralizing mutations in the S4 segment of Shaker channels.

The Journal of general physiology - 1 Jan 1999

Bao H, Hakeem A, Henteleff M, Starkus J G, Rayner M D

Abstract excerpt

Shaker channel mutants, in which the first (R362), second (R365), and fourth (R371) basic residues in the S4 segment have been neutralized, are found to pass potassium currents with voltage-insensitive kinetics when expressed in Xenopus oocytes. Single channel recordings clarify that these channels continue to open and close from -160 to +80 mV with a constant opening probability (Po). Although Po is low (...

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Identifiers

PMID: 9874694
DOI: 10.1085/jgp.113.1.139
PMCID: PMC2222989

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Voltage-insensitive gating after charge-neutralizing mutations in the S4 segment of Shaker channels.PMID 9874694Read ↗

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