Article
Voltage-insensitive gating after charge-neutralizing mutations in the S4 segment of Shaker channels.
The Journal of general physiology - 1 Jan 1999
Bao H, Hakeem A, Henteleff M, Starkus J G, Rayner M D
Abstract excerpt
Shaker channel mutants, in which the first (R362), second (R365), and fourth (R371) basic residues in the S4 segment have been neutralized, are found to pass potassium currents with voltage-insensitive kinetics when expressed in Xenopus oocytes. Single channel recordings clarify that these channe...
Topics
- Algorithms
- Animals
- Electric Stimulation
- Electrophysiology
- Ion Channel Gating
- Membrane Potentials
- Mice
- Models, Biological
- Mutation
- Oocytes
- Patch-Clamp Techniques
- Potassium Channels
- Shaker Superfamily of Potassium Channels
- Xenopus laevis