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Article

Non-native R1 substitution in the s4 domain uniquely alters Kv4.3 channel gating.

PloS one - 1 Jan 2008

Skerritt Matthew R, Campbell Donald L

Abstract excerpt

The S4 transmembrane domain in Shaker (Kv1) voltage-sensitive potassium channels has four basic residues (R1-R4) that are responsible for carrying the majority of gating charge. In Kv4 channels, however, R1 is replaced by a neutral valine at position 287. Among other differences, Kv4 channels display prominent closed state inactivation, a mechanism which is minimal in Shaker. To determine if the absence of R1 is...

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Identifiers

PMID: 19020667
DOI: 10.1371/journal.pone.0003773
PMCID: PMC2582947

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Non-native R1 substitution in the s4 domain uniquely alters Kv4.3 channel gating.PMID 19020667Read ↗

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