Article
Tracking a complete voltage-sensor cycle with metal-ion bridges.
Proceedings of the National Academy of Sciences of the United States of America - 29 May 2012
Henrion Ulrike, Renhorn Jakob, Börjesson Sara I, Nelson Erin M, Schwaiger Christine S, Bjelkmar Pär, Wallner Björn, Lindahl Erik, Elinder Fredrik
Abstract excerpt
Voltage-gated ion channels open and close in response to changes in membrane potential, thereby enabling electrical signaling in excitable cells. The voltage sensitivity is conferred through four voltage-sensor domains (VSDs) where positively charged residues in the fourth transmembrane segment (S4) sense the potential. While an open state is known from the Kv1.2/2.1 X-ray structure, the conformational changes...
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