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Article

S4 mutations alter the single-channel gating kinetics of Shaker K+ channels.

Neuron - 1 Aug 1993

Shao X M, Papazian D M

Abstract excerpt

The S4 sequence comprises at least part of the voltage sensor in Shaker K+ channels. Two site-directed mutations in the Shaker S4 sequence, R368Q and R377K, which decrease the voltage dependence of the whole-cell current, alter voltage-dependent gating at the single-channel level. Compared with the wild-type channel, they increase the latency to first opening, destabilize the open state, and alter the equilibria...

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PMID: 8352942
DOI: 10.1016/0896-6273(93)90189-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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