Article
S4 mutations alter the single-channel gating kinetics of Shaker K+ channels.
Neuron - 1 Aug 1993
Shao X M, Papazian D M
Abstract excerpt
The S4 sequence comprises at least part of the voltage sensor in Shaker K+ channels. Two site-directed mutations in the Shaker S4 sequence, R368Q and R377K, which decrease the voltage dependence of the whole-cell current, alter voltage-dependent gating at the single-channel level. Compared with t...
Topics
- Animals
- Animals, Wild
- Drosophila
- Electrophysiology
- Ion Channel Gating
- Kinetics
- Mutation
- Potassium Channels