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Article

Functional interactions at the interface between voltage-sensing and pore domains in the Shaker K(v) channel.

Neuron - 22 Nov 2006

Soler-Llavina Gilberto J, Chang Tsg-Hui, Swartz Kenton J

Abstract excerpt

Voltage-activated potassium (K(v)) channels contain a central pore domain that is partially surrounded by four voltage-sensing domains. Recent X-ray structures suggest that the two domains lack extensive protein-protein contacts within presumed transmembrane regions, but whether this is the case for functional channels embedded in lipid membranes remains to be tested. We investigated domain interactions in the...

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Source

Identifiers

PMID: 17114047
DOI: 10.1016/j.neuron.2006.10.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional interactions at the interface between voltage-sensing and pore domains in the Shaker K(v) channel.PMID 17114047Read ↗

Electrostatic interactions between transmembrane segments mediate folding of Shaker K+ channel subunits.Semantic proximity Read ↗

Voltage-dependent structural interactions in the Shaker K(+) channel.Semantic proximity Read ↗

Role of hydrophobic and ionic forces in the movement of S4 of the Shaker potassium channel.Semantic proximity Read ↗

The isolated voltage sensing domain of the Shaker potassium channel forms a voltage-gated cation channel.Semantic proximity Read ↗

Reciprocal voltage sensor-to-pore coupling leads to potassium channel C-type inactivation.Semantic proximity Read ↗

Gating of shaker-type channels requires the flexibility of S6 caused by prolines.Semantic proximity Read ↗

Nonsensing residues in S3-S4 linker's C terminus affect the voltage sensor set point in K+ channels.Semantic proximity Read ↗

The orientation and molecular movement of a k(+) channel voltage-sensing domain.Semantic proximity Read ↗

Atomic proximity between S4 segment and pore domain in Shaker potassium channels.Semantic proximity Read ↗

Mutations in the S6 gate isolate a late step in the activation pathway and reduce 4-AP sensitivity in shaker K(v) channel.Semantic proximity Read ↗

S4 mutations alter the single-channel gating kinetics of Shaker K+ channels.Semantic proximity Read ↗

A characterization of the activating structural rearrangements in voltage-dependent Shaker K+ channels.Semantic proximity Read ↗

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