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Article

A role for the S0 transmembrane segment in voltage-dependent gating of BK channels.

The Journal of general physiology - 1 Mar 2007

Koval Olga M, Fan Yun, Rothberg Brad S

Abstract excerpt

BK (Maxi-K) channel activity is allosterically regulated by a Ca2+ sensor, formed primarily by the channel's large cytoplasmic carboxyl tail segment, and a voltage sensor, formed by its transmembrane helices. As with other voltage-gated K channels, voltage sensing in the BK channel is accomplished through interactions of the S1-S4 transmembrane segments with the electric field. However, the BK channel is unique...

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Source

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Identifiers

PMID: 17296928
DOI: 10.1085/jgp.200609662
PMCID: PMC2151615

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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A role for the S0 transmembrane segment in voltage-dependent gating of BK channels.PMID 17296928Read ↗

Nonsensing residues in S3-S4 linker's C terminus affect the voltage sensor set point in K+ channels.Semantic proximity Read ↗

An S6 mutation in BK channels reveals beta1 subunit effects on intrinsic and voltage-dependent gating.Semantic proximity Read ↗

Structural basis of voltage-dependent gating in BK channels.Semantic proximity Read ↗

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BK channel opening involves side-chain reorientation of multiple deep-pore residues.Semantic proximity Read ↗

Coupling of Ca <sup>2+</sup> and voltage activation in BK channels through the αB helix/voltage sensor interfaceSemantic proximity Read ↗

Mutations in the S6 gate isolate a late step in the activation pathway and reduce 4-AP sensitivity in shaker K(v) channel.Semantic proximity Read ↗

The conserved phenylalanine in the K+ channel voltage-sensor domain creates a barrier with unidirectional effects.Semantic proximity Read ↗

Mechanism of voltage sensing in Ca2+- and voltage-activated K+ (BK) channels.Semantic proximity Read ↗

Coupling between residues on S4 and S1 defines the voltage-sensor resting conformation in NaChBac.Semantic proximity Read ↗

Hydrophobic substitution mutations in the S4 sequence alter voltage-dependent gating in Shaker K+ channels.Semantic proximity Read ↗

Intramolecular interactions that control voltage sensitivity in the jShak1 potassium channel from Polyorchis penicillatus.Semantic proximity Read ↗

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