Hydrophobic substitution mutations in the S4 sequence alter voltage-dependent gating in Shaker K+ channels.

doi:10.1016/0896-6273(91)90271-z

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Article

Hydrophobic substitution mutations in the S4 sequence alter voltage-dependent gating in Shaker K+ channels.

Neuron - 1 Aug 1991

Lopez G A, Jan Y N, Jan L Y

Abstract excerpt

Voltage-activated Na+, Ca2+, and K+ channels contain a common motif, the S4 sequence, characterized by a basic residue at every third position interspersed mainly with hydrophobic residues. The S4 sequence is proposed to function as the voltage sensor and to move in response to membrane depolariz...

Topics

Amino Acid Sequence
Animals
Electric Conductivity
Female
Ion Channel Gating
Membrane Potentials
Membrane Proteins
Molecular Sequence Data
Mutation
Oocytes
Potassium Channels
Xenopus laevis

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