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Article

A genomewide suppressor and enhancer analysis of cdc13-1 reveals varied cellular processes influencing telomere capping in Saccharomyces cerevisiae.

Genetics - 1 Dec 2008

Addinall S G, Downey M, Yu M, Zubko M K, Dewar J, Leake A, Hallinan J, Shaw O, James K, Wilkinson D J, Wipat A, Durocher D, Lydall D

Abstract excerpt

In Saccharomyces cerevisiae, Cdc13 binds telomeric DNA to recruit telomerase and to "cap" chromosome ends. In temperature-sensitive cdc13-1 mutants telomeric DNA is degraded and cell-cycle progression is inhibited. To identify novel proteins and pathways that cap telomeres, or that respond to uncapped telomeres, we combined cdc13-1 with the yeast gene deletion collection and used high-throughput spot-test assays...

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Identifiers

PMID: 18845848
DOI: 10.1534/genetics.108.092577
PMCID: PMC2600956

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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