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Article

Molecular Defects of the Disease-Causing Human Arrestin-1 C147F Mutant.

Investigative ophthalmology & visual science - 1 Jan 2018

Vishnivetskiy Sergey A, Sullivan Lori S, Bowne Sara J, Daiger Stephen P, Gurevich Eugenia V, Gurevich Vsevolod V

Abstract excerpt

Purpose: The purpose of this study was to identify the molecular defect in the disease-causing human arrestin-1 C147F mutant. Methods: The binding of wild-type (WT) human arrestin-1 and several mutants with substitutions in position 147 (including C147F, which causes dominant retinitis pigmentosa in humans) to phosphorylated and unphosphorylated light-activated rhodopsin was determined. Thermal stability of WT...

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Identifiers

PMID: 29305604
DOI: 10.1167/iovs.17-22180
PMCID: PMC5756042

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Source receipt: pubmed, retrieved 7 Sept 2026.

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