Article
The role of arrestin-1 N-edge in rhodopsin binding.
Cellular signalling - 1 Oct 2025
Vishnivetskiy Sergey A, Gurevich Eugenia V, Gurevich Vsevolod V
Abstract excerpt
Arrestin-1, in contrast to other subtypes, demonstrates exquisite selectivity for the active phosphorylated form of its cognate receptor, rhodopsin. The loop between β-strands IX and X, termed N-edge because it is located on the distal tip of the N-domain in the folded arrestin molecule, was implicated in the binding of arrestin-1 and -2 to their cognate receptors. We performed alanine scanning and charge...
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