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Targeting individual GPCRs with redesigned nonvisual arrestins.

Handbook of experimental pharmacology - 1 Jan 2014

Gimenez Luis E, Vishnivetskiy Sergey A, Gurevich Vsevolod V

Abstract excerpt

Numerous human diseases are caused by excessive signaling of mutant G protein-coupled receptors (GPCRs) or receptors that are overstimulated due to upstream signaling imbalances. The feasibility of functional compensation by arrestins with enhanced ability to quench receptor signaling was recently tested in the visual system. The results showed that even in this extremely demanding situation of rods that have no...

Topics

Animals
Arrestins
Humans
Mutation
Phosphates
Phosphorylation
Receptors, G-Protein-Coupled
Retinal Rod Photoreceptor Cells
Rhodopsin
Signal Transduction

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Identifiers

PMID: 24292829
DOI: 10.1007/978-3-642-41199-1_8
PMCID: PMC4516156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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