Article
Functional role of the three conserved cysteines in the N domain of visual arrestin-1.
The Journal of biological chemistry - 28 Jul 2017
Vishnivetskiy Sergey A, Lee Regina J, Zhou X Edward, Franz Andreas, Xu Qiuyi, Xu H Eric, Gurevich Vsevolod V
Abstract excerpt
Arrestins specifically bind active and phosphorylated forms of their cognate G protein-coupled receptors, blocking G protein coupling and often redirecting the signaling to alternative pathways. High-affinity receptor binding is accompanied by two major structural changes in arrestin: release of the C-tail and rotation of the two domains relative to each other. The first requires detachment of the arrestin C-tail...
Topics
- Animals
- Arrestins
- Cysteine
- Mutation
- Phosphorylation
- Protein Domains
- Rabbits