Enhanced arrestin facilitates recovery and protects rods lacking rhodopsin phosphorylation.

doi:10.1016/j.cub.2009.02.065

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Article

Enhanced arrestin facilitates recovery and protects rods lacking rhodopsin phosphorylation.

Current biology : CB - 28 Apr 2009

Song Xiufeng, Vishnivetskiy Sergey A, Gross Owen P, Emelianoff Katrina, Mendez Ana, Chen Jeannie, Gurevich Eugenia V, Burns Marie E, Gurevich Vsevolod V

Abstract excerpt

G protein-coupled receptors (GPCRs) are the largest family of signaling proteins expressed in every cell in the body and are targeted by the majority of clinically used drugs [1]. GPCR signaling, including rhodopsin-driven phototransduction, is terminated by receptor phosphorylation followed by arrestin binding [2]. Genetic defects in receptor phosphorylation and excessive signaling by overactive GPCR mutants...

Topics

Animals
Arrestin
Electroretinography
G-Protein-Coupled Receptor Kinase 1
Mice
Mice, Knockout
Mutation
Phosphorylation
Retinal Rod Photoreceptor Cells
Rhodopsin

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Identifiers

PMID: 19361994
DOI: 10.1016/j.cub.2009.02.065
PMCID: PMC2768495

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