β-Arrestins and disease-linked variants: opportunities for targeted modulation.

Abstract excerpt

G protein-coupled receptors orchestrate numerous physiological processes and represent the largest class of drug targets, yet their intracellular regulators, the β-arrestins, remain largely underexplored. Despite their crucial roles in receptor desensitization, trafficking, and signaling, few modulators have been identified, with limited isoform selectivity. Therapeutic efforts have mainly focused on...

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