Article
Enhanced phosphorylation-independent arrestins and gene therapy.
Handbook of experimental pharmacology - 1 Jan 2014
Gurevich Vsevolod V, Song Xiufeng, Vishnivetskiy Sergey A, Gurevich Eugenia V
Abstract excerpt
A variety of heritable and acquired disorders is associated with excessive signaling by mutant or overstimulated GPCRs. Since any conceivable treatment of diseases caused by gain-of-function mutations requires gene transfer, one possible approach is functional compensation. Several structurally distinct forms of enhanced arrestins that bind phosphorylated and even non-phosphorylated active GPCRs with much higher...
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