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Article

Custom-designed proteins as novel therapeutic tools? The case of arrestins.

Expert reviews in molecular medicine - 23 Apr 2010

Gurevich Vsevolod V, Gurevich Eugenia V

Abstract excerpt

Multiple genetic disorders can be associated with excessive signalling by mutant G-protein-coupled receptors (GPCRs) that are either constitutively active or have lost sites where phosphorylation by GPCR kinases is necessary for desensitisation by cognate arrestins. Phosphorylation-independent arrestin1 can compensate for defects in phosphorylation of the GPCR rhodopsin in retinal rod cells, facilitating...

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Identifiers

PMID: 20412604
DOI: 10.1017/S1462399410001444
PMCID: PMC2933791

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Custom-designed proteins as novel therapeutic tools? The case of arrestins.PMID 20412604Read ↗

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