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Article

Degree of Tissue Differentiation Dictates Susceptibility to BRAF-Driven Colorectal Cancer.

Cell reports - 26 Dec 2017

Tong Kevin, Pellón-Cárdenas Oscar, Sirihorachai Veerin R, Warder Bailey N, Kothari Om A, Perekatt Ansu O, Fokas Emily E, Fullem Robert L, Zhou Anbo, Thackray Joshua K, Tran Hiep, Zhang Lanjing, Xing Jinchuan, Verzi Michael P

Abstract excerpt

Oncogenic mutations in BRAF are believed to initiate serrated colorectal cancers; however, the mechanisms of BRAF-driven colon cancer are unclear. We find that oncogenic BRAF paradoxically suppresses stem cell renewal and instead promotes differentiation. Correspondingly, tumor formation is inefficient in BRAF-driven mouse models of colon cancer. By reducing levels of differentiation via genetic manipulation of...

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Identifiers

PMID: 29281831
DOI: 10.1016/j.celrep.2017.11.104
PMCID: PMC5747303

Genes

BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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