Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tissue-location-specific transcription programs drive tumor dependencies in colon cancer

15 Feb 2024

Abstract excerpt

Abstract Cancers of the same tissue-type but in anatomically distinct locations exhibit different molecular dependencies for tumorigenesis. Proximal and distal colon cancers exemplify such characteristics, with BRAFV600E predominantly occurring in proximal colon cancers along with increased DNA methylation phenotype. Using mouse colon organoids, here we show that proximal and distal colon stem cells have distinct...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Digestive system and related health
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38360902
DOI: 10.1038/s41467-024-45605-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tissue-location-specific transcription programs drive tumor dependencies in colon cancerPMID 38360902Read ↗

Tissue-location specific transcription programs drive tumor initiation dependencies in colon cancerSemantic proximity Read ↗

The Lineage-Specific Transcription Factor CDX2 Navigates Dynamic Chromatin to Control Distinct Stages of Intestine DevelopmentSemantic proximity Read ↗

The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non–cell-autonomous mechanismsSemantic proximity Read ↗

Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation.Semantic proximity Read ↗

Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancerSemantic proximity Read ↗

Epithelial de-differentiation triggered by co-ordinate epigenetic inactivation of the EHF and CDX1 transcription factors drives colorectal cancer progressionSemantic proximity Read ↗

Aberrant cell state plasticity mediated by developmental reprogramming precedes colorectal cancer initiationSemantic proximity Read ↗

Degree of Tissue Differentiation Dictates Susceptibility to BRAF-Driven Colorectal Cancer.Semantic proximity Read ↗

BRAFV600E cooperates with CDX2 inactivation to promote serrated colorectal tumorigenesisSemantic proximity Read ↗

Cdx2 Controls Expression of the Protocadherin Mucdhl, an Inhibitor of Growth and β-Catenin Activity in Colon Cancer CellsSemantic proximity Read ↗

Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell propertiesSemantic proximity Read ↗

Current understanding and clinical utility of miRNAs regulation of colon cancer stem cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.