Article
BRAF: a driver of the serrated pathway in colon cancer.
Cancer cell - 8 Jul 2013
Rustgi Anil K
Abstract excerpt
In this issue of Cancer Cell, Rad and colleagues report findings that underscore the importance of oncogenic BRAF mutation coupled with microsatellite instability, p16Ink4a inactivation, and p53 mutation in the serrated pathway of colon cancer development. These findings provide translational insights into potential therapeutic intervention for BRAF mutant colon cancers.
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