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Article

MOLECULAR FEATURES AND MOUSE MODELS OF COLORECTAL CANCER.

Transactions of the American Clinical and Climatological Association - 1 Jan 2018

Fearon Eric R

Abstract excerpt

Colorectal cancers (CRCs) harbor accumulated defects in key signaling pathways that regulate cell phenotypes, including proliferation, survival, metabolism, and differentiation. To study the functional contributions of the accumulated molecular defects in CRC, we have developed approaches to inactivate selected tumor suppressor and/or activate oncogenes in mouse colon epithelium. Conditional inactivation of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30166699
PMCID: PMC6116608

Genes

BRAF
CDX2

Provenance

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