BRAFV600E cooperates with CDX2 inactivation to promote serrated colorectal tumorigenesis

Abstract excerpt

While 20–30% of colorectal cancers (CRCs) may arise from precursors with serrated glands, only 8–10% of CRCs manifest serrated morphology at diagnosis. Markers for distinguishing CRCs arising from ‘serrated’ versus ‘conventional adenoma’ precursors are lacking. We studied 36 human serrated CRCs and found CDX2 loss or BRAF mutations in ~60% of cases and often together (p = 0.04). CDX2 Null /BRAF V600E expression...

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