A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention.

doi:10.1016/j.ccr.2013.05.014

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Article

A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention.

Cancer cell - 8 Jul 2013

Rad Roland, Cadiñanos Juan, Rad Lena, Varela Ignacio, Strong Alexander, Kriegl Lydia, Constantino-Casas Fernando, Eser Stefan, Hieber Maren, Seidler Barbara, Price Stacey, Fraga Mario F, Calvanese Vincenzo, Hoffman Gary, Ponstingl Hannes, Schneider Günter, Yusa Kosuke, Grove Carolyn, Schmid Roland M, Wang Wei, Vassiliou George, Kirchner Thomas, McDermott Ultan, Liu Pentao, Saur Dieter, Bradley Allan

Abstract excerpt

We show that BRAF(V600E) initiates an alternative pathway to colorectal cancer (CRC), which progresses through a hyperplasia/adenoma/carcinoma sequence. This pathway underlies significant subsets of CRCs with distinctive pathomorphologic/genetic/epidemiologic/clinical characteristics. Genetic and functional analyses in mice revealed a series of stage-specific molecular alterations driving different phases of...

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PMID: 23845441
DOI: 10.1016/j.ccr.2013.05.014
PMCID: PMC3706745

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BRAF

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