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BRAFV600E-mutated serrated colorectal neoplasia drives transcriptional activation of cholesterol metabolism

21 Sept 2023

Abstract excerpt

Abstract BRAF mutations occur early in serrated colorectal cancers, but their long-term influence on tissue homeostasis is poorly characterized. We investigated the impact of short-term (3 days) and long-term (6 months) expression of BrafV600E in the intestinal tissue of an inducible mouse model. We show that BrafV600E perturbs the homeostasis of intestinal epithelial cells, with impaired differentiation of...

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PMID: 37735514
DOI: 10.1038/s42003-023-05331-x

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