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Article

Significant association between catechol-O-methyltransferase (COMT) Val158/108Met polymorphism and cognitive function in veterans with PTSD.

Neuroscience letters - 14 Feb 2018

Havelka Mestrovic Ana, Tudor Lucija, Nikolac Perkovic Matea, Nedic Erjavec Gordana, Kovacic Petrovic Zrnka, Svob Strac Dubravka, Konjevod Marcela, Pivac Nela

Abstract excerpt

Core features of posttraumatic stress disorder (PTSD) are cognitive disturbances. Enzyme catechol-O-methyltransferase (COMT) degrades dopamine primarily in prefrontal cortex. Its functional polymorphism, COMT Val158/108Met, affects COMT activity and dopamine availability and is associated with disturbances in cognition. The hypothesis was that PTSD subjects will have worse working memory than healthy controls and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29248614
DOI: 10.1016/j.neulet.2017.12.033

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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