COMT Val158Met polymorphism is associated with post-traumatic stress disorder and functional outcome following mild traumatic brain injury.

doi:10.1016/j.jocn.2016.09.017

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Article

COMT Val158Met polymorphism is associated with post-traumatic stress disorder and functional outcome following mild traumatic brain injury.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia - 1 Jan 2017

Winkler Ethan A, Yue John K, Ferguson Adam R, Temkin Nancy R, Stein Murray B, Barber Jason, Yuh Esther L, Sharma Sourabh, Satris Gabriela G, McAllister Thomas W, Rosand Jonathan, Sorani Marco D, Lingsma Hester F, Tarapore Phiroz E, Burchard Esteban G, Hu Donglei, Eng Celeste, Wang Kevin K W, Mukherjee Pratik, Okonkwo David O, Diaz-Arrastia Ramon, Manley Geoffrey T

Abstract excerpt

Mild traumatic brain injury (mTBI) results in variable clinical trajectories and outcomes. The source of variability remains unclear, but may involve genetic variations, such as single nucleotide polymorphisms (SNPs). A SNP in catechol-o-methyltransferase (COMT) is suggested to influence development of post-traumatic stress disorder (PTSD), but its role in TBI remains unclear. Here, we utilize the Transforming...

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Identifiers

PMID: 27769642
DOI: 10.1016/j.jocn.2016.09.017
PMCID: PMC5588892

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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