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Article

The effect of COMT Val158Met and DRD2 C957T polymorphisms on executive function and the impact of early life stress.

Brain and behavior - 1 May 2017

Klaus Kristel, Butler Kevin, Durrant Simon J, Ali Manir, Inglehearn Chris F, Hodgson Timothy L, Gutierrez Humberto, Pennington Kyla

Abstract excerpt

INTRODUCTION: Previous research has indicated that variation in genes encoding catechol-O-methyltransferase (COMT) and dopamine receptor D2 (DRD2) may influence cognitive function and that this may confer vulnerability to the development of mental health disorders such as schizophrenia. However, increasing evidence suggests environmental factors such as early life stress may interact with genetic variants in...

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Source

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Identifiers

PMID: 28523234
DOI: 10.1002/brb3.695
PMCID: PMC5434197

Genes

DRD2
COMT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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