Article
COMT Val 158 Met polymorphism is associated with nonverbal cognition following mild traumatic brain injury.
Neurogenetics - 1 Jan 2016
Winkler Ethan A, Yue John K, McAllister Thomas W, Temkin Nancy R, Oh Sam S, Burchard Esteban G, Hu Donglei, Ferguson Adam R, Lingsma Hester F, Burke John F, Sorani Marco D, Rosand Jonathan, Yuh Esther L, Barber Jason, Tarapore Phiroz E, Gardner Raquel C, Sharma Sourabh, Satris Gabriela G, Eng Celeste, Puccio Ava M, Wang Kevin K W, Mukherjee Pratik, Valadka Alex B, Okonkwo David O, Diaz-Arrastia Ramon, Manley Geoffrey T
Abstract excerpt
Mild traumatic brain injury (mTBI) results in variable clinical outcomes, which may be influenced by genetic variation. A single-nucleotide polymorphism in catechol-o-methyltransferase (COMT), an enzyme which degrades catecholamine neurotransmitters, may influence cognitive deficits following moderate and/or severe head trauma. However, this has been disputed, and its role in mTBI has not been studied. Here, we...
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