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Article

The risk of posttraumatic stress disorder after trauma depends on traumatic load and the catechol-o-methyltransferase Val(158)Met polymorphism.

Biological psychiatry - 15 Feb 2010

Kolassa Iris-Tatjana, Kolassa Stephan, Ertl Verena, Papassotiropoulos Andreas, De Quervain Dominique J-F

Abstract excerpt

BACKGROUND: The risk for posttraumatic stress disorder (PTSD) depends on the number of traumatic event types experienced in a dose-response relationship, but genetic factors are known to also influence the risk of PTSD. The catechol-O-methyltransferase (COMT) Val158Met polymorphism has been found to affect fear extinction and might play a role in the etiology of anxiety disorders. METHODS: Traumatic load and...

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Africa
Catechol O-Methyltransferase
Chi-Square Distribution
Life Change Events
Methionine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Stress Disorders, Post-Traumatic

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PMID: 19944409
DOI: 10.1016/j.biopsych.2009.10.009

Genes

COMT

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The risk of posttraumatic stress disorder after trauma depends on traumatic load and the catechol-o-methyltransferase Val(158)Met polymorphism.PMID 19944409Read ↗

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