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Article

COMT Val158Met polymorphism moderates the association between PTSD symptom severity and hippocampal volume.

Journal of psychiatry & neuroscience : JPN - 1 Mar 2017

Hayes Jasmeet P, Logue Mark W, Reagan Andrew, Salat David, Wolf Erika J, Sadeh Naomi, Spielberg Jeffrey M, Sperbeck Emily, Hayes Scott M, McGlinchey Regina E, Milberg William P, Verfaellie Mieke, Stone Annjanette, Schichman Steven A, Miller Mark W

Abstract excerpt

BACKGROUND: Memory-based alterations are among the hallmark symptoms of posttraumatic stress disorder (PTSD) and may be associated with the integrity of the hippocampus. However, neuroimaging studies of hippocampal volume in individuals with PTSD have yielded inconsistent results, raising the possibility that various moderators, such as genetic factors, may influence this association. We examined whether the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28234210
DOI: 10.1503/jpn.150339
PMCID: PMC5373706

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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