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Article

Association of COMT Val158Met genotype with executive functioning following traumatic brain injury.

The Journal of neuropsychiatry and clinical neurosciences - 1 Jan 2005

Lipsky Robert H, Sparling Molly B, Ryan Laurie M, Xu Ke, Salazar Andres M, Goldman David, Warden Deborah L

Abstract excerpt

Catechol-O-methyltransferase (COMT) is thought to functionally modulate dopamine neurons, thus likely influencing frontal-executive functioning. High enzyme activity (COMT Val) and low enzyme activity (COMT Met) are functional polymorphisms resulting from a G to A transition in exon 4 (codon 158) of the human COMT gene. Decreased cortical dopamine should result in poorer executive functioning. Therefore, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16387984
DOI: 10.1176/jnp.17.4.465

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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