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Article

Catechol-O-methyltransferase val158met genotype determines effect of reboxetine on emotional memory in healthy male volunteers.

Journal of psychiatry & neuroscience : JPN - 1 May 2014

Gibbs Ayana A, Bautista Carla E, Mowlem Florence D, Naudts Kris H, Duka Dora T

Abstract excerpt

BACKGROUND: Catechol-O-methyltransferase (COMT) metabolizes catecholamines in the prefrontal cortex (PFC). A common polymorphism in the COMT gene (COMT val158met) has pleiotropic effects on cognitive and emotional processing. The met allele has been associated with enhanced cognitive processing but impaired emotional processing relative to the val allele. METHODS: We genotyped healthy, white men in relation to...

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Source

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Identifiers

PMID: 24467942
DOI: 10.1503/jpn.130131
PMCID: PMC3997609

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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