Article
Catechol-O-methyltransferase (COMT) val158met polymorphism as a risk factor for PTSD after urban violence.
Journal of molecular neuroscience : MN - 1 Mar 2011
Valente Nina Leão Marques, Vallada Homero, Cordeiro Quirino, Bressan Rodrigo Affonseca, Andreoli Sergio Baxter, Mari Jair Jesus, Mello Marcelo Feijó
Abstract excerpt
PTSD is a psychiatric disorder that requires a traumatic event as diagnostic criteria. Brazil has high rates of violence, and it is expected that urban victims of violence would be at risk to the development of PTSD. Studies have associated the COMT val158met polymorphism with diminished stress resilience, reduced ability to extinguish conditioned fear, and the development of PTSD after multiple traumatic...
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