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Article

Drosophila Syd-1 Has RhoGAP Activity That Is Required for Presynaptic Clustering of Bruchpilot/ELKS but Not Neurexin-1.

Genetics - 1 Feb 2018

Spinner Michael A, Walla David A, Herman Tory G

Abstract excerpt

Syd-1 proteins are required for presynaptic development in worm, fly, and mouse. Syd-1 proteins in all three species contain a Rho GTPase activating protein (GAP)-like domain of unclear significance: invertebrate Syd-1s are thought to lack GAP activity, and mouse mSYD1A has GAP activity that is thought to be dispensable for its function. Here, we show that Drosophila melanogaster Syd-1 can interact with all six...

Topics

Animals
Calcium-Binding Proteins
Cell Adhesion Molecules, Neuronal
Drosophila
Drosophila Proteins
GTPase-Activating Proteins
Models, Molecular
Motor Neurons
Mutation
Nerve Tissue Proteins
Neural Cell Adhesion Molecules

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neuromuscular Junction

Protein Binding

cdc42 GTP-Binding Protein

rac1 GTP-Binding Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 29217522
DOI: 10.1534/genetics.117.300538
PMCID: PMC5788532

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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