The Liprin homology domain is essential for the homomeric interaction of SYD-2/Liprin-α protein in presynaptic assembly.

doi:10.1523/JNEUROSCI.0002-11.2011

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Article

The Liprin homology domain is essential for the homomeric interaction of SYD-2/Liprin-α protein in presynaptic assembly.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 9 Nov 2011

Taru Hidenori, Jin Yishi

Abstract excerpt

Synapses are asymmetric structures that are specialized for neuronal signal transduction. A unique set of proteins is present at the presynaptic active zone, which is a core structure essential for neurotransmitter release. In Caenorhabditis elegans HSN neurons, SYD-2, a Liprin-α family protein, acts together with a GAP protein SYD-1 to promote presynaptic assembly. Previous studies have shown that elevating the...

Topics

Adaptor Proteins, Signal Transducing
Animals
Animals, Genetically Modified
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Cell Line, Transformed
Chlorocebus aethiops
Gene Expression Regulation
Green Fluorescent Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Intercellular Signaling Peptides and Proteins

Motor Neurons

Mutation

Phosphoproteins

Presynaptic Terminals

Protein Structure, Tertiary

Synapses

Source

Open in PubMed Open full text

Identifiers

PMID: 22072677
DOI: 10.1523/JNEUROSCI.0002-11.2011
PMCID: PMC3500560

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The Liprin homology domain is essential for the homomeric interaction of SYD-2/Liprin-α protein in presynaptic assembly.PMID 22072677Read ↗

SYD-2 Liprin-alpha organizes presynaptic active zone formation through ELKS.Semantic proximity Read ↗

Intramolecular regulation of presynaptic scaffold protein SYD-2/liprin-α.Semantic proximity Read ↗

Hierarchical assembly of presynaptic components in defined C. elegans synapses.Semantic proximity Read ↗

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The C2H2 zinc-finger protein SYD-9 is a putative posttranscriptional regulator for synaptic transmission.Semantic proximity Read ↗

Systematic analyses of rpm-1 suppressors reveal roles for ESS-2 in mRNA splicing in Caenorhabditis elegans.Semantic proximity Read ↗

Assembly of synaptic active zones requires phase separation of scaffold molecules.Semantic proximity Read ↗

NAB-1 instructs synapse assembly by linking adhesion molecules and F-actin to active zone proteins.Semantic proximity Read ↗

The presynaptic dense projection of the Caenorhabditis elegans cholinergic neuromuscular junction localizes synaptic vesicles at the active zone through SYD-2/liprin and UNC-10/RIM-dependent interactions.Semantic proximity Read ↗

HLB-1 functions as a new regulator for the organization and function of neuromuscular junctions in nematode Caenorhabditis elegans.Semantic proximity Read ↗

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