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Article

Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein.

Cell - 10 Nov 2000

Bowman A B, Kamal A, Ritchings B W, Philp A V, McGrail M, Gindhart J G, Goldstein L S

Abstract excerpt

A broadly conserved membrane-associated protein required for the functional interaction of kinesin-I with axonal cargo was identified. Mutations in sunday driver (syd) and the axonal transport motor kinesin-I cause similar phenotypes in Drosophila, including aberrant accumulations of axonal cargoes. GFP-tagged mammalian SYD localizes to tubulovesicular structures that costain for kinesin-I and a marker of the...

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PMID: 11106729
DOI: 10.1016/s0092-8674(00)00162-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein.PMID 11106729Read ↗

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The microtubule-binding protein ensconsin is an essential cofactor of kinesin-1.Semantic proximity Read ↗

PTP-3 phosphatase promotes intramolecular folding of SYD-2 to inactivate kinesin-3 UNC-104 in neurons.Semantic proximity Read ↗

Normal dynactin complex function during synapse growth in Drosophila requires membrane binding by Arfaptin.Semantic proximity Read ↗

Kinesin-II is required for axonal transport of choline acetyltransferase in Drosophila.Semantic proximity Read ↗

Intramolecular regulation of presynaptic scaffold protein SYD-2/liprin-α.Semantic proximity Read ↗

A STRIPAK complex mediates axonal transport of autophagosomes and dense core vesicles through PP2A regulation.Semantic proximity Read ↗

Axonal transport defects are a common phenotype in Drosophila models of ALS.Semantic proximity Read ↗

The liprin protein SYD-2 regulates the differentiation of presynaptic termini in C. elegans.Semantic proximity Read ↗

The Liprin homology domain is essential for the homomeric interaction of SYD-2/Liprin-α protein in presynaptic assembly.Semantic proximity Read ↗

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