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Article

Inhibition of Rac by the GAP activity of centralspindlin is essential for cytokinesis.

Science (New York, N.Y.) - 5 Dec 2008

Canman Julie C, Lewellyn Lindsay, Laband Kimberley, Smerdon Stephen J, Desai Arshad, Bowerman Bruce, Oegema Karen

Abstract excerpt

During cytokinesis, the guanosine triphosphatase (GTPase) RhoA orchestrates contractile ring assembly and constriction. RhoA signaling is controlled by the central spindle, a set of microtubule bundles that forms between the separating chromosomes. Centralspindlin, a protein complex consisting of the kinesin-6 ZEN-4 and the Rho family GTPase activating protein (GAP) CYK-4, is required for central spindle assembly...

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Source

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Identifiers

PMID: 19056985
DOI: 10.1126/science.1163086
PMCID: PMC2736296

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of Rac by the GAP activity of centralspindlin is essential for cytokinesis.PMID 19056985Read ↗

CYK-4: A Rho family gtpase activating protein (GAP) required for central spindle formation and cytokinesis.Semantic proximity Read ↗

The chromosomal passenger complex and centralspindlin independently contribute to contractile ring assembly.Semantic proximity Read ↗

Cooperative assembly of CYK-4/MgcRacGAP and ZEN-4/MKLP1 to form the centralspindlin complex.Semantic proximity Read ↗

CYK-4 functions independently of its centralspindlin partner ZEN-4 to cellularize oocytes in germline syncytiaSemantic proximity Read ↗

An ECT2-centralspindlin complex regulates the localization and function of RhoA.Semantic proximity Read ↗

RhoA activation during polarization and cytokinesis of the early <i>Caenorhabditis elegans</i> embryo is differentially dependent on NOP-1 and CYK-4Semantic proximity Read ↗

Cytokinesis: GAP gap.Semantic proximity Read ↗

The MgcRacGAP SxIP motif tethers Centralspindlin to microtubule plus ends in Xenopus laevis.Semantic proximity Read ↗

Recruitment of cortexillin into the cleavage furrow is controlled by Rac1 and IQGAP-related proteins.Semantic proximity Read ↗

ZEN-4/MKLP1 is required to polarize the foregut epithelium.Semantic proximity Read ↗

Mechanisms for concentrating Rho1 during cytokinesis.Semantic proximity Read ↗

Mutations in sticky lead to defective organization of the contractile ring during cytokinesis and are enhanced by Rho and suppressed by Rac.Semantic proximity Read ↗

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