Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NAB-1 instructs synapse assembly by linking adhesion molecules and F-actin to active zone proteins.

Nature neuroscience - 8 Jan 2012

Chia Poh Hui, Patel Maulik R, Shen Kang

Abstract excerpt

During synaptogenesis, macromolecular protein complexes assemble at the pre- and postsynaptic membrane. Extensive literature identifies many transmembrane molecules sufficient to induce synapse formation and several intracellular scaffolding molecules responsible for assembling active zones and recruiting synaptic vesicles. However, little is known about the molecular mechanisms coupling membrane receptors to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules
Share to Immunoglobulins
Share to Luminescent Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Microfilament Proteins

Share to Motor Neurons

Share to Presynaptic Terminals

Share to Synapses

Share to Synaptic Vesicles

Source

Open in PubMed Open full text

Identifiers

PMID: 22231427
DOI: 10.1038/nn.2991
PMCID: PMC3848868

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NAB-1 instructs synapse assembly by linking adhesion molecules and F-actin to active zone proteins.PMID 22231427Read ↗

Hierarchical assembly of presynaptic components in defined C. elegans synapses.Semantic proximity Read ↗

Neuronal polarity is regulated by a direct interaction between a scaffolding protein, Neurabin, and a presynaptic SAD-1 kinase in Caenorhabditis elegans.Semantic proximity Read ↗

A Syd-1 homologue regulates pre- and postsynaptic maturation in Drosophila.Semantic proximity Read ↗

RSY-1 is a local inhibitor of presynaptic assembly in C. elegans.Semantic proximity Read ↗

The Liprin homology domain is essential for the homomeric interaction of SYD-2/Liprin-α protein in presynaptic assembly.Semantic proximity Read ↗

Caenorhabditis elegans SORB-1 localizes to integrin adhesion sites and is required for organization of sarcomeres and mitochondria in myocytes.Semantic proximity Read ↗

Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca(2+) channel-vesicle coupling.Semantic proximity Read ↗

An SCF-like ubiquitin ligase complex that controls presynaptic differentiation.Semantic proximity Read ↗

SYD-2 Liprin-alpha organizes presynaptic active zone formation through ELKS.Semantic proximity Read ↗

The liprin protein SYD-2 regulates the differentiation of presynaptic termini in C. elegans.Semantic proximity Read ↗

Neurobeachin is required postsynaptically for electrical and chemical synapse formation.Semantic proximity Read ↗

Axon development is regulated at genetic and proteomic interfaces between the integrin adhesome and the RPM-1 ubiquitin ligase signaling hubSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.