Article
NAB-1 instructs synapse assembly by linking adhesion molecules and F-actin to active zone proteins.
Nature neuroscience - 8 Jan 2012
Chia Poh Hui, Patel Maulik R, Shen Kang
Abstract excerpt
During synaptogenesis, macromolecular protein complexes assemble at the pre- and postsynaptic membrane. Extensive literature identifies many transmembrane molecules sufficient to induce synapse formation and several intracellular scaffolding molecules responsible for assembling active zones and recruiting synaptic vesicles. However, little is known about the molecular mechanisms coupling membrane receptors to...
Topics
- Actins
- Animals
- Animals, Genetically Modified
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cell Adhesion Molecules
- Cell Movement
- Gene Expression Regulation, Developmental
- Immunoglobulins
- Intercellular Signaling Peptides and Proteins
- Larva
- Luminescent Proteins
- Microfilament Proteins