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Article

NSD1 inactivation defines an immune cold, DNA hypomethylated subtype in squamous cell carcinoma.

Scientific reports - 6 Dec 2017

Brennan Kevin, Shin June Ho, Tay Joshua K, Prunello Marcos, Gentles Andrew J, Sunwoo John B, Gevaert Olivier

Abstract excerpt

Chromatin modifying enzymes are frequently mutated in cancer, resulting in widespread epigenetic deregulation. Recent reports indicate that inactivating mutations in the histone methyltransferase NSD1 define an intrinsic subtype of head and neck squamous cell carcinoma (HNSC) that features pronounced DNA hypomethylation. Here, we describe a similar hypomethylated subtype of lung squamous cell carcinoma (LUSC)...

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Share to CD8-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone-Lysine N-Methyltransferase

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Source

Open in PubMed Open full text

Identifiers

PMID: 29213088
DOI: 10.1038/s41598-017-17298-x
PMCID: PMC5719078

Genes

NSD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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