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Article

Chromatin dysregulation associated with NSD1 mutation in head and neck squamous cell carcinoma.

Cell reports - 23 Feb 2021

Farhangdoost Nargess, Horth Cynthia, Hu Bo, Bareke Eric, Chen Xiao, Li Yinglu, Coradin Mariel, Garcia Benjamin A, Lu Chao, Majewski Jacek

Abstract excerpt

Chromatin dysregulation has emerged as an important mechanism of oncogenesis. To develop targeted treatments, it is important to understand the transcriptomic consequences of mutations in chromatin modifier genes. Recently, mutations in the histone methyltransferase gene nuclear receptor binding SET domain protein 1 (NSD1) have been identified in a subset of common and deadly head and neck squamous cell...

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Identifiers

PMID: 33626351
DOI: 10.1016/j.celrep.2021.108769
PMCID: PMC8006058

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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