Article

NSD1 inactivation defines an immune cold, DNA hypomethylated subtype in squamous cell carcinoma

2017-10-20

Abstract excerpt

Chromatin modifying enzymes are frequently mutated in cancer, resulting in a cascade of epigenetic deregulation. Recent reports indicate that inactivating mutations in the histone methyltransferase NSD1 define an intrinsic subtype of head and neck squamous cell carcinoma (HNSC) that features widespread DNA hypomethylation. Here, we describe a similar DNA hypomethylated subtype of lung squamous cell carcinoma (LUSC...

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Literature Corpus work: 5bba902a-35cc-5442-a201-88de14f6a921
DOI: 10.1101/178608

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