Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Elevated NSD3 histone methylation activity drives squamous cell lung cancer.

Nature - 1 Feb 2021

Yuan Gang, Flores Natasha M, Hausmann Simone, Lofgren Shane M, Kharchenko Vladlena, Angulo-Ibanez Maria, Sengupta Deepanwita, Lu Xiaoyin, Czaban Iwona, Azhibek Dulat, Vicent Silvestre, Fischle Wolfgang, Jaremko Mariusz, Fang Bingliang, Wistuba Ignacio I, Chua Katrin F, Roth Jack A, Minna John D, Shao Ning-Yi, Jaremko Łukasz, Mazur Pawel K, Gozani Or

Abstract excerpt

Amplification of chromosomal region 8p11-12 is a common genetic alteration that has been implicated in the aetiology of lung squamous cell carcinoma (LUSC)1-3. The FGFR1 gene is the main candidate driver of tumorigenesis within this region4. However, clinical trials evaluating FGFR1 inhibition as a targeted therapy have been unsuccessful5. Here we identify the histone H3 lysine 36 (H3K36) methyltransferase NSD3,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Methylation
Share to Biocatalysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinogenesis

Share to Carcinoma, Squamous Cell

Share to Histone-Lysine N-Methyltransferase

Share to Histones

Share to Receptor, Fibroblast Growth Factor, Type 1

Share to Xenograft Model Antitumor Assays

Source

Open in PubMed Open full text

Identifiers

PMID: 33536620
DOI: 10.1038/s41586-020-03170-y
PMCID: PMC7895461

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Elevated NSD3 histone methylation activity drives squamous cell lung cancer.PMID 33536620Read ↗

NSD3 in Cancer: Unraveling Methyltransferase-Dependent and Isoform-Specific FunctionsSemantic proximity Read ↗

KDM7B-mediated demethylation of RNF113A regulates small cell lung cancer sensitivity to alkylation damageSemantic proximity Read ↗

Chromatin dysregulation associated with NSD1 mutation in head and neck squamous cell carcinoma.Semantic proximity Read ↗

Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases.Semantic proximity Read ↗

The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas.Semantic proximity Read ↗

Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3.3K36M oncohistone mutation.Semantic proximity Read ↗

NSD1 inactivation defines an immune cold, DNA hypomethylated subtype in squamous cell carcinoma.Semantic proximity Read ↗

Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas.Semantic proximity Read ↗

The Role of Nuclear Receptor-Binding SET Domain Family Histone Lysine Methyltransferases in Cancer.Semantic proximity Read ↗

NSD1- and NSD2-damaging mutations define a subset of laryngeal tumors with favorable prognosis.Semantic proximity Read ↗

Systematic perturbations of SETD2, NSD1, NSD2, NSD3 and ASH1L reveals their distinct contributions to H3K36 methylationSemantic proximity Read ↗

NSD1 inactivation defines an immune cold, DNA hypomethylated subtype in squamous cell carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.