Article
Disruption of NSD1 in Head and Neck Cancer Promotes Favorable Chemotherapeutic Responses Linked to Hypomethylation.
Molecular cancer therapeutics - 1 Jul 2018
Bui Nam, Huang Justin K, Bojorquez-Gomez Ana, Licon Katherine, Sanchez Kyle S, Tang Sean N, Beckett Alex N, Wang Tina, Zhang Wei, Shen John Paul, Kreisberg Jason F, Ideker Trey
Abstract excerpt
Human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) represents a distinct classification of cancer with worse expected outcomes. Of the 11 genes recurrently mutated in HNSCC, we identify a singular and substantial survival advantage for mutations in the gene encoding Nuclear Set Domain Containing Protein 1 (NSD1), a histone methyltransferase altered in approximately 10% of patients....
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