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Article

Identification of an atypical etiological head and neck squamous carcinoma subtype featuring the CpG island methylator phenotype.

EBioMedicine - 1 Mar 2017

Brennan K, Koenig J L, Gentles A J, Sunwoo J B, Gevaert O

Abstract excerpt

Head and neck squamous cell carcinoma (HNSCC) is broadly classified into HNSCC associated with human papilloma virus (HPV) infection, and HPV negative HNSCC, which is typically smoking-related. A subset of HPV negative HNSCCs occur in patients without smoking history, however, and these etiologically 'atypical' HNSCCs disproportionately occur in the oral cavity, and in female patients, suggesting a distinct...

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Share to Carcinoma, Squamous Cell
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CpG Islands

Share to DNA Methylation

Share to Gene Expression Regulation, Neoplastic

Share to Head and Neck Neoplasms

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Source

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Identifiers

PMID: 28314692
DOI: 10.1016/j.ebiom.2017.02.025
PMCID: PMC5360591

Genes

CASP8
SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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