Article

Overcoming Therapeutic Resistance in Head and Neck Squamous Cell Carcinoma (HNSCC)—The Role of Histone Demethylase and Methyltransferase Inhibitors

2026-05-05

Abstract excerpt

Despite advances in multimodal treatment, head and neck squamous cell carcinoma (HNSCC) remains a major clinical problem owing to its high recurrence rate and frequent development of treatment resistance. Abnormal histone modifications, particularly lysine methylation regulated by methyltransferases (KMTs) and demethylases (KDMs), have emerged as key drivers of HNSCC initiation, progression, and cellular plasticit...

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Literature Corpus work: ca52fd95-abc3-5689-9089-5ef319092330
DOI: 10.20944/preprints202605.0261.v1

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