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Article

The NSD family of protein methyltransferases in human cancer.

Epigenomics - 1 Aug 2015

Vougiouklakis Theodore, Hamamoto Ryuji, Nakamura Yusuke, Saloura Vassiliki

Abstract excerpt

The NSD family of protein lysine methyltransferases consists of NSD1, NSD2/WHSC1/MMSET and NSD3/WHSC1L1. NSD2 haploinsufficiency causes Wolf-Hirschhorn syndrome, while NSD1 mutations lead to the Sotos syndrome. Recently, a number of studies showed that the NSD methyltransferases were overexpressed, amplified or somatically mutated in multiple types of cancer, suggesting their critical role in cancer. These...

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Share to Antineoplastic Agents
Share to Histone-Lysine N-Methyltransferase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25942451
DOI: 10.2217/epi.15.32

Genes

NSD1
NSD2
NSD3
RELA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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