Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NSD1- and NSD2-damaging mutations define a subset of laryngeal tumors with favorable prognosis.

Nature communications - 24 Nov 2017

Peri Suraj, Izumchenko Evgeny, Schubert Adrian D, Slifker Michael J, Ruth Karen, Serebriiskii Ilya G, Guo Theresa, Burtness Barbara A, Mehra Ranee, Ross Eric A, Sidransky David, Golemis Erica A

Abstract excerpt

Squamous cell carcinomas of the head and neck (SCCHN) affect anatomical sites including the oral cavity, nasal cavity, pharynx, and larynx. Laryngeal cancers are characterized by high recurrence and poor overall survival, and currently lack robust molecular prognostic biomarkers for treatment stratification. Using an algorithm for integrative clustering that simultaneously assesses gene expression, somatic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression Regulation, Neoplastic
Share to Histone-Lysine N-Methyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone Methyltransferases

Share to Intracellular Signaling Peptides and Proteins

Share to Laryngeal Neoplasms

Share to Nuclear Proteins

Share to Repressor Proteins

Share to Squamous Cell Carcinoma of Head and Neck

Source

Open in PubMed Open full text

Identifiers

PMID: 29176703
DOI: 10.1038/s41467-017-01877-7
PMCID: PMC5701248

Genes

NSD1
NSD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NSD1- and NSD2-damaging mutations define a subset of laryngeal tumors with favorable prognosis.PMID 29176703Read ↗

NSD1 inactivation defines an immune cold, DNA hypomethylated subtype in squamous cell carcinoma.Semantic proximity Read ↗

IDH2 R172 Mutations Across Poorly Differentiated Sinonasal Tract Malignancies: Forty Molecularly Homogenous and Histologically Variable Cases With Favorable Outcome.Semantic proximity Read ↗

Disruption of NSD1 in Head and Neck Cancer Promotes Favorable Chemotherapeutic Responses Linked to Hypomethylation.Semantic proximity Read ↗

Chromatin dysregulation associated with NSD1 mutation in head and neck squamous cell carcinoma.Semantic proximity Read ↗

Development and validation of epigenetic signature predict survival for patients with laryngeal squamous cell carcinomaSemantic proximity Read ↗

NSD1 inactivation defines an immune cold, DNA hypomethylated subtype in squamous cell carcinomaSemantic proximity Read ↗

A multi-omics approach to identify prognostic subtypes and therapeutic targets in head and neck squamous cell carcinomaSemantic proximity Read ↗

Mutational analysis of head and neck squamous cell carcinoma stratified by smoking statusSemantic proximity Read ↗

Promoter DNA methylation patterns in oral, laryngeal and oropharyngeal anatomical regions are associated with tumor differentiation, nodal involvement and survivalSemantic proximity Read ↗

Identifying targeted cell-free DNA methylation regions in head and neck cancer via paired methylome analysisSemantic proximity Read ↗

Expression Profile, Prognostic Value, and Therapeutic Potential of NSD2 in Pan-Cancer: A Systematic Analysis Integrating Multi-Omics DataSemantic proximity Read ↗

NSD1 mutations by HPV status in head and neck cancer: differences in survival and response to DNA-damaging agentsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.