Article
RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies.
Acta biochimica et biophysica Sinica - 1 Jan 2016
Fang Bingliang
Abstract excerpt
Activating mutations of oncogenic RAS genes are frequently detected in human cancers. The studies in genetically engineered mouse models (GEMMs) reveal that Kras-activating mutations predispose mice to early onset tumors in the lung, pancreas, and gastrointestinal tract. Nevertheless, most of the...
Topics
- Adenocarcinoma
- Alleles
- Animals
- Cell Line, Tumor
- Clinical Trials as Topic
- Gene Expression Regulation, Neoplastic
- Genetic Engineering
- Humans
- Mice
- Mutation
- Neoplasm Metastasis
- Neoplasms
- Phenotype
- Phosphatidylinositol 3-Kinases
- Precision Medicine
- Signal Transduction
- ras Proteins